W. N. Aldridge (eds.)'s A Symposium on Mechanisms of Toxicity PDF

By W. N. Aldridge (eds.)

ISBN-10: 1349010855

ISBN-13: 9781349010851

ISBN-10: 1349010871

ISBN-13: 9781349010875

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A. Ronzio, W. B. Rowe, J. D. Gass, & S. L. N. Rao CHa I I CH2 I 0=S=N-P0a 2 - CH2 I CHNHa+ I coo- FIG. 12. Possible structures of methionine sulphoximine phosphate. synthetase in the absence of added nucleotide and metal ions. However, L-methionine sulphoximine phosphate inhibits the enzyme much more effectively when magnesium ions and ADP (and to a lesser extent ATP) are also added. The ability of glutamine synthetase to catalyse the phosphorylation of methionine sulphoximine is in accord with the acyl phosphate hypothesis expressed earlier.

M phenylacetaldehyde at 30°C and at pH 7·2 in a total volume of 3·0 ml and the production of phenylacetaldehyde ,8-phenylethylhydrazone was followed spectrophotometrically at 235 nm ( 0). The time course of inhibition of the enzyme activity toward benzylamine is also shown <•>· Monoamine Oxidase Inhibitors 23 0·12 ""'· ............ ~. ___ ----· OL-------------~5~------------~10~----------~15° Time (min) FIG. 7. Non-enzymic reaction of ,8-phenylethylhydrazine with phenylacetaldehyde. M ,8-phenylethylhydrazine.

REFERENCES ARIENS, A. , WOLTHUIS, 0. L. & VAN BENTHEM, R. M. J. (1969). , COSTINESCU, H. & TICHESCU, G. (1966). Revista Sanitara Militara (Roumenia), 62, 499 FISCHER, G. (1968). Histochemie, 16, 144 HuLsT, S. G. TH. & DE WIED, D. (1967). Physiol. , HADDOW, J. , KIND, C. & CocKBURN, F. (1968). Metabolism, 17, 1094 KRIVOGLAZ, B. A. (1965). In Klinika i Lecheniye Intoksikatsiy, p. 32. , (February 1966), report 34, p. 180 LoMAX, P. & JENDEN, D. J. (1966). Int. J. , 5, 353 MEETER, E. (1969). Archs int.

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A Symposium on Mechanisms of Toxicity by W. N. Aldridge (eds.)


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