Get Analysis of Neuropeptides by Liquid Chromatography and Mass PDF

By Dominic M. Desiderio

ISBN-10: 0444424180

ISBN-13: 9780444424181

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Extra info for Analysis of Neuropeptides by Liquid Chromatography and Mass Spectrometry

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5 nm), while inserting a 6Gly s h i f t s t h e remaining amino acid sequence towards the C-terminus by that same distance. 3) must be rigidly maintained within 0 . 5 nm. The novel opioid octapeptide dynorphinl-8 is proposed to exist in the intermediate pituitary of r a t s where the peptide is isolated by immunoabsorption to antibodies directed against porcine dynorphinl-13 ( 6 9 ) . -1 The opioid octapeptide may occur at a level of almost one pmol rng within the neurointermediate pituitary of rats.

Prolactin 32. insulin another area ( F I ) may derive from the dynorphin system. It was noted that there is apparently a complex and critical relationship amongst several experimental parameters - anatomically defining neuronal distribution of opioid peptides , CSF sampling procedures, technical constraints associated with that sampling, and the functional state in the neurons being investigated (See also Chapter 3 ) . Data are presented to support the positive correlation between endorphin levels in CSF and measures of pain ( 9 0 ) .

Dynorphinergic pathways. Dynorphin A 29 The peptide bond between 18Lys and '('Arg in this large dynorphin precursor is significant because trypsin-like cleavage of that bond generates an amino terminal heptadecapeptirlc (dynorphin A ) and a carboxy terminal . tridecapeptide (dynorphin B ) The latter peptide, dynorphin U , represents t h e third "big" LE besides dynorphin A and alpha-neoendorphin (Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro-Lys). Thc dynorphin 13 molecule suprisingly displays t h e same high kappa receptor activity as dynorphin A, a fact which indicates that t h e "address" needed for receptor recognition and binding most probably resides in the N-termini of the two peptides.

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Analysis of Neuropeptides by Liquid Chromatography and Mass Spectrometry by Dominic M. Desiderio


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